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Drug Safety Matters
Drug Safety Matters brings you the best stories from the world of pharmacovigilance. Through in-depth interviews with our guests, we cover new research and trends, and explore the most pressing issues in medicines safety today. Produced by Uppsala Monitoring Centre, the WHO Collaborating Centre for International Drug Monitoring.
The views and opinions expressed in the podcast are those of the hosts and guests respectively and, unless otherwise stated, do not represent the position of any institution to which they are affiliated.
Drug Safety Matters
#12 Improving signal detection with vigiGroup – Jim Barrett & Joe Mitchell
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Statistical tools can not only cut through the noise in large pharmacovigilance databases. They can also help identify more clinically meaningful patterns in the data. Uppsala Monitoring Centre’s Jim Barrett and Joe Mitchell explain how vigiGroup, a novel clustering algorithm, can bring value to signal detection.
Tune in to find out:
- What the limits of traditional disproportionality analysis are
- How clustering algorithms can improve current signal detection practices
- How vigiGroup has helped monitor the safety of COVID-19 vaccines so far
Want to know more?
- By applying vigiGroup to COVID-19 vaccine reports in VigiBase, our Research team was able to identify a number of potential safety signals. Find out more in this poster or in this presentation.
- Details on how the vigiGroup method was developed and tested can be found in the original publication in Artificial Intelligence in Medicine.
- Appendicitis was one of the possible safety signals for the COVID-19 vaccines identified with vigiGroup.
For more on signal detection at Uppsala Monitoring Centre, visit the Signal Work section on our website or listen to this interview with Helena Sköld and Annette Rudolph on vaccine pharmacovigilance.
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